Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...

Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.

Depression: Overview

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...

Restorative Care

Restorative Care

Restorative care is provided once a patient has been discharged from a healthcare facility and requires additional services. The additional services include home care, rehabilitation programs, and extended care. Restorative care centers help the patient regain their previous level of functioning or acquire a new level of functioning due to the incapacitating effects of a disease or a disability. It aims to assist patients in enhancing their quality of life by encouraging independence,...

Depressive Disorders: MDD and Dysthymia

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...

Depressive Disorders: Etiology

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Phase 1 trial of pre-operative image guided intensity modulated photon radiotherapy with simultaneously integrated boost to the high-risk margin for patients with retroperitoneal sarcoma.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026

Same author

A Pile of Books.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry·2026

Same author

Memoriam for James A. Greene, MD, DLFAPA, FACPsych.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry·2026

Same author

You Just Don't Get It! Social Isolation, Loneliness, and Social Cognition.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry·2026

Same author

Safety and feasibility of talimogene laherparepvec in peritoneal surface malignancies: Results from the TEMPO trial.

Molecular therapy. Oncology·2026

Same author

A health and economic evaluation of the spatial spillover effect from measles resurgence.

Scientific reports·2025

Search research articles

Related Experiment Video

Updated: Jul 7, 2026

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

Published on: September 30, 2020

Depression in long-term care.

Mugdha Thakur¹, Dan G Blazer

¹Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA. mugdha.thakur@duke.edu

Journal of the American Medical Directors Association

|February 12, 2008

Summary

Depression affects up to 35% of long-term care residents but is often missed. Early diagnosis and treatment, including medication and other therapies, can effectively manage depressive disorders in this population.

Area of Science:

Geriatric Medicine
Psychiatry
Long-Term Care

Background:

Depressive disorders are prevalent in long-term care facilities, affecting a significant portion of residents.
Underdiagnosis is common due to lack of focus and comorbidity with other conditions like cognitive impairment and medical illness.

Purpose of the Study:

To review the diagnosis and treatment of depressive disorders specifically within long-term care settings.

Main Methods:

Literature review focusing on depression diagnosis and treatment in long-term care environments.

Main Results:

Up to 35% of long-term care residents experience major depression or significant depressive symptoms.
Depression is frequently unrecognized due to insufficient clinical focus and co-occurrence with other health issues.

Related Experiment Videos

Last Updated: Jul 7, 2026

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

Published on: September 30, 2020

Effective treatment is achievable in nursing homes, with pharmacotherapy as a primary approach, supplemented by exercise and psychological therapies.

Conclusions:

Depression in long-term care, though often overlooked, is a treatable condition.
Comprehensive attention from medical and nursing staff is crucial for addressing depression in this setting.