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Abnormal development of the human cerebral cortex: genetics, functional consequences and treatment options

Renzo Guerrini1, William B Dobyns, A James Barkovich

  • 1Department of Neurology and Neurosurgery, Children's Hospital A. Meyer, University of Florence, Viale Pieraccini 24, 50139, Florence, Italy. r.guerrini@meyer.it

Trends in Neurosciences
|February 12, 2008
PubMed
Summary

Genetic studies reveal genes disrupting cortical development, leading to malformations like focal cortical dysplasia. These conditions can cause neurological deficits and drug-resistant epilepsy, often requiring complex surgical planning.

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