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Hepatocyte growth factor modulates Sertoli-Sertoli tight junction dynamics

A Catizone1, G Ricci, M Galdieri

  • 1Department of Histology and Medical Embryology, School of Medicine, University of Rome Sapienza, Rome, Italy.

Journal of Cellular Physiology
|February 12, 2008
PubMed
Summary

Hepatocyte growth factor (HGF) reduces occludin in mammalian testes, impacting Sertoli cell tight junctions and spermatogenesis. HGF also increases active TGF-beta via urokinase-type plasminogen activator (uPA).

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