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Sequence databases: integrated information retrieval and data submission
J M Weisemann1, M S Boguski, B F Ouellette
1National Center for Biotechnology Information, Bethesda, Maryland, USA.
Current Protocols in Molecular Biology
|February 12, 2008
Summary
This unit explores biomedical information resources, including sequence and structure data, literature, and database entry processes. Key databases like MEDLINE, GenBank, and Entrez are discussed.
Area of Science:
- Biomedical Informatics
- Bioinformatics
- Scientific Databases
Background:
- Biomedical research relies heavily on accessible and organized information resources.
- Understanding the origin and structure of biological data is crucial for scientific advancement.
Purpose of the Study:
- To provide a comprehensive overview of essential biomedical information resources.
- To elucidate the process of nucleotide sequence data submission into public databases.
- To highlight key databases for accessing sequence, structure, and literature information.
Main Methods:
- Literature review and synthesis of information regarding major biomedical databases.
- Description of data types including nucleotide sequences and protein structures.
- Explanation of data curation and integration processes within databases.
Main Results:
- Overview of critical biomedical databases such as MEDLINE, GenBank, and Entrez.
- Explanation of the pathway for nucleotide sequence data entering public repositories.
- Identification of resources for accessing biological sequence, structure, and associated scientific literature.
Conclusions:
- Effective utilization of biomedical databases is fundamental for researchers.
- Knowledge of data provenance enhances the reliability and interpretation of biological information.
- Databases like GenBank and Entrez serve as vital hubs for biomedical data access and discovery.
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