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Sequence databases: integrated information retrieval and data submission.

J M Weisemann1, M S Boguski, B F Ouellette

  • 1National Center for Biotechnology Information, Bethesda, Maryland, USA.

Current Protocols in Molecular Biology
|February 12, 2008
PubMed
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This unit explores biomedical information resources, including sequence and structure data, literature, and database entry processes. Key databases like MEDLINE, GenBank, and Entrez are discussed.

Area of Science:

  • Biomedical Informatics
  • Bioinformatics
  • Scientific Databases

Background:

  • Biomedical research relies heavily on accessible and organized information resources.
  • Understanding the origin and structure of biological data is crucial for scientific advancement.

Purpose of the Study:

  • To provide a comprehensive overview of essential biomedical information resources.
  • To elucidate the process of nucleotide sequence data submission into public databases.
  • To highlight key databases for accessing sequence, structure, and literature information.

Main Methods:

  • Literature review and synthesis of information regarding major biomedical databases.
  • Description of data types including nucleotide sequences and protein structures.

Related Experiment Videos

  • Explanation of data curation and integration processes within databases.

    • Main Results:

    • Overview of critical biomedical databases such as MEDLINE, GenBank, and Entrez.
    • Explanation of the pathway for nucleotide sequence data entering public repositories.
    • Identification of resources for accessing biological sequence, structure, and associated scientific literature.

    Conclusions:

    • Effective utilization of biomedical databases is fundamental for researchers.
    • Knowledge of data provenance enhances the reliability and interpretation of biological information.
    • Databases like GenBank and Entrez serve as vital hubs for biomedical data access and discovery.