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Updated: Jul 7, 2026
11:17
Direct Measurement of KDM1A Target Engagement Using Chemoprobe-based Immunoassays
Published on: June 13, 2019
[Recognition of KD]
1JAPAN Kawasaki Disease Research Center.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|February 12, 2008
Summary
Pediatricians identified a unique cluster of symptoms in children, later recognized as Kawasaki disease. Early recognition was challenging due to its novelty in medical literature.
Area of Science:
- Pediatrics
- Rheumatology
- Infectious Diseases
Context:
- The study details the initial encounters with a novel pediatric illness characterized by a unique symptom complex.
- The author, a pediatrician, observed patients with symptoms not matching existing medical literature.
- The initial cases were seen between 1961 and 1962 in Tokyo, Japan.
Purpose:
- To document and describe a previously unrecognized clinical syndrome in children.
- To highlight the diagnostic challenges posed by this new disease entity.
- To lay the groundwork for the formal description and naming of the condition.
Summary:
- The author encountered several pediatric patients exhibiting a consistent and unusual set of clinical signs and symptoms.
- These symptoms did not align with any known diseases described in medical texts at the time.
- The author's observations led to the eventual identification and publication of the 'Infantile Acute febrile Muco-cutaneous lymph node syndrome', now known as Kawasaki disease.
Impact:
- This work led to the formal recognition and naming of Kawasaki disease, a significant vasculitis affecting children.
- It provided the foundational clinical description for future research and diagnostic criteria.
- The early case series was crucial for raising awareness among the medical community about this distinct pediatric condition.
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