Bootstrapped two-electrode biosignal amplifier
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Updated: Jul 7, 2026

Multi-analyte Biochip (MAB) Based on All-solid-state Ion-selective Electrodes (ASSISE) for Physiological Research
Published on: April 18, 2013
Dobromir Petkov Dobrev1, Tatyana Neycheva, Nikolay Mudrov
1Centre of Biomedical Engineering Ivan Daskalov, Bulgarian Academy of Sciences, Acad. G. Bonchev str., Block 105, 1113, Sofia, Bulgaria. dobri@clbme.bas.bg
Abstract:
Portable biomedical instrumentation has become an important part of diagnostic and treatment instrumentation. Low-voltage and low-power tendencies prevail. A two-electrode biopotential amplifier, designed for low-supply voltage (2.7-5.5 V), is presented. This biomedical amplifier design has high differential and sufficiently low common mode input impedances achieved by means of positive feedback, implemented with an original interface stage. The presented circuit makes use of passive components of popular values and tolerances. The amplifier is intended for use in various two-electrode applications, such as Holter monitors, external defibrillators, ECG monitors and other heart beat sensing biomedical devices.
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