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Published on: June 21, 2021

Thioredoxin reductase-1 knock down does not result in thioredoxin-1 oxidation

Walter H Watson1, Jacqueline M Heilman, Laura L Hughes

  • 1Johns Hopkins Bloomberg School of Public Health, Department of Environmental Health Sciences, Division of Toxicology, 615 N. Wolfe Street, Room E7545, Baltimore, MD 21205, USA.

Biochemical and Biophysical Research Communications
|February 13, 2008
PubMed
Summary

Inhibiting thioredoxin reductase-1 (TrxR1) alone does not oxidize thioredoxin-1 (Trx1). Only monomethylarsonous acid (MMA(III)) exposure oxidized Trx1 and increased reactive oxygen species (ROS), indicating Trx1-independent pathways are involved.

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