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Parkinson's Disease: Treatment

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...

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Updated: Jul 7, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

Deep brain stimulation for Parkinson's disease.

¹Department of Neurology, Christian-Albrechts-University, Kiel, Germany. j.volkmann@neurologie.uni-kiel.de

Parkinsonism & Related Disorders

|November 19, 2008

Summary

Deep brain stimulation of the subthalamic nucleus is a standard treatment for Parkinson's disease. For selected patients, it offers better quality of life than oral medications.

Area of Science:

Neurology
Neurosurgery

Background:

Subthalamic nucleus deep brain stimulation (DBS) is a common therapy for Parkinson's disease motor symptoms.
Key predictors for surgical success include levodopa responsiveness, normal cognition, and younger age.

Purpose of the Study:

To evaluate the efficacy of subthalamic nucleus DBS compared to oral therapy for Parkinson's disease patients meeting specific criteria.
To assess the impact on health-related quality of life.

Main Methods:

Analysis of existing evidence on subthalamic nucleus DBS for Parkinson's disease.
Comparison of outcomes between surgical intervention and standard oral drug therapy.

Main Results:

Subthalamic nucleus DBS is effective for motor fluctuations, dyskinesia, and tremor in Parkinson's disease.

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Patient selection based on levodopa response, cognition, and age is crucial for optimal outcomes.

DBS demonstrated superiority over oral therapy in maintaining quality of life for eligible patients.

Conclusions:

Deep brain stimulation of the subthalamic nucleus is a superior treatment option for carefully selected Parkinson's disease patients.
Optimizing patient selection enhances the benefits of subthalamic nucleus DBS, improving quality of life.