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The composition of the inflammatory infiltrate in three cases of polyneuritis equi
G van Galen1, D Cassart, C Sandersen
1Department of Clinical Science, Equine Section, Faculty of Veterinary Medicine, University of Liege, Boulevard de Colonster 20, B41 Liege, Belgium.
Abstract:
Polyneuritis equi (PNE) is a rare neurological disease in the horse. Because of the suspicion in PNE of a T-lymphocyte mediated immune response against the myelin, the objective of this study was to determine the composition of the inflammatory infiltrate in the involved nerves of 3 horses with PNE, studied retrospectively. T-lymphocytes were demonstrated in the lesions, which suggests a T-lymphocyte mediated immune response against myelin. In addition, the presence of B-lymphocytes indicated a local production of antibodies. More research, involving a prospective study, is needed to determine whether the T-lymphocytes are cytotoxic or T-helper lymphocytes.
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