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Local metabolic, pathophysiological and histological changes in venous ulcers
1Department of Vascular Surgery, Institute of Cardiovascular Diseases, Clinical Centre of Serbia, Belgrade. trimax@EUnet.yu
Differences in venous blood gases and metabolites suggest distinct causes for superficial venous (SU) ulcers versus deep venous (DU) ulcers. This finding may impact diagnosis and treatment strategies for venous ulceration.
Area of Science:
- Vascular Medicine
- Dermatology
- Biochemistry
Background:
- The exact mechanisms behind venous ulceration remain unclear.
- Understanding differences between superficial venous (SU) and deep venous (DU) ulcers is crucial for effective treatment.
Purpose of the Study:
- To compare venous blood gases and anaerobic metabolites in SU and DU ulcers.
- To investigate potential differences in the pathogenesis of SU versus DU ulcers.
Main Methods:
- Analysis of venous blood gases and anaerobic metabolites from ulcer sites in SU (n=8) and DU (n=8) patients.
- Comparison with control samples from healthy limbs.
- Electron microscopy of ulcer tissue samples from SU (n=2) and DU (n=2) patients.
Main Results:
- SU ulcers showed lower partial oxygen pressure (pO2) and oxygen saturation (sO2), with higher carbon dioxide levels compared to controls.
- DU ulcers exhibited higher pO2 and sO2 than controls.
- DU ulcers had elevated pyruvate and lactate levels after passive standing, but no significant histological differences were found between SU and DU samples.
Conclusions:
- Distinct venous blood gas and metabolite profiles suggest different causal pathways for SU and DU ulcers.
- These findings may hold clinical significance for diagnosing and treating venous ulceration.
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