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Updated: Jul 7, 2026
06:56
Generating a Fractal Microstructure of Laminin-111 to Signal to Cells
Published on: September 28, 2020
The 67 kDa laminin receptor: structure, function and role in disease
John Nelson1, Neil V McFerran, Géraldine Pivato
1School of Biological Sciences, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK.
Bioscience Reports
|February 14, 2008
Summary
The 67 kDa laminin receptor (67LR) is a cell-surface protein involved in cell adhesion, tumor metastasis, and viral entry. Its precursor, 37 kDa laminin receptor precursor (37LRP), has unclear maturation and diverse functions.
Area of Science:
- Cell Biology
- Molecular Biology
- Biochemistry
Background:
- The 67 kDa laminin receptor (67LR) is a cell-surface protein crucial for cell adhesion and signaling.
- It plays a significant role in tumor cell metastasis.
- 67LR is derived from a smaller precursor, 37 kDa laminin receptor precursor (37LRP).
Purpose of the Study:
- To review the current understanding of 67LR structure and function.
- To elucidate the mechanism of 37LRP to 67LR conversion.
- To highlight areas for future research on 67LR.
Main Methods:
- Literature review of existing studies on 67LR and 37LRP.
- Analysis of protein structure and function relationships.
- Discussion of cellular localization and molecular interactions.
Main Results:
- 67LR binds laminin with high affinity, mediating cell adhesion and signal transduction.
- The conversion of 37LRP to 67LR may involve post-translational modifications like fatty acylation and dimerization.
- 67LR also functions as a receptor for viruses and in prion protein internalization.
Conclusions:
- 67LR is a multifunctional protein with roles beyond laminin binding.
- Further research is needed to clarify the 37LRP to 67LR maturation process and nuclear interactions.
- Understanding 67LR is critical for cell adhesion, metastasis, and infectious disease research.
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