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Updated: Jul 7, 2026
Organotypic Retinal Explant Cultures from Macaque Monkey
Published on: August 24, 2022
Multiple ophthalmic abnormalities in an infant rhesus macaque (Macaca mulatta)
Erin P Ribka1, Richard R Dubielzig
1Division of Veterinary Medicine, Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA. eribka@tulane.edu
This study details a rhesus macaque eye initially diagnosed with keratitis, later found to have goniodysgenesis and optic nerve atrophy. These findings highlight complex ocular conditions in macaques.
Area of Science:
- Veterinary ophthalmology
- Primate pathology
- Comparative ocular disease
Background:
- A young Indian rhesus macaque presented with severe right eye trauma, hyphema, and corneal edema.
- Initial enucleation and histopathology suggested chronic keratitis.
Observation:
- A delayed diagnosis of goniodysgenesis was made years later.
- The affected eye was re-examined by a veterinary ocular pathologist for definitive diagnosis.
Findings:
- Final conclusions identified anterior segment and corneal defects.
- Retinal and optic nerve pathology revealed optic nerve atrophy, a newly documented condition in macaques.
Implications:
- This case underscores the importance of thorough, long-term ocular evaluation in non-human primates.
- It contributes to understanding optic nerve atrophy in macaques, aiding future diagnostics and research.
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