[Effect of local anesthetics on the dental pulp. Study in rats]

According to the in vitro and in vivo procedures described by Rockert and Pracros, the effect of different local anesthetics (with and without vaso-constrictive solution) have been studied on rat incisor dental pulp. Histological analysis (optical microscopy) of samples (90 rat incisors) showed: A systematic pulp response with concentrations up to 2%. This response correspond with a toxic reaction on the respiratory activity of pulp cells; A highest response with solutions containing a vaso-constrictor additive; An increasing response according to the nature of the anesthetic solution.