Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nanoparticle inhalation augments particle-dependent systemic microvascular dysfunction.

Timothy R Nurkiewicz1, Dale W Porter, Ann F Hubbs

  • 1Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, Morgantown, WV, USA. tnurkiewicz@hsc.wvu.edu.

Particle and Fibre Toxicology
|February 14, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Inhalation exposure to surrogate military burn pit emissions impairs systemic microvascular function: linking pulmonary insult and diverse peripheral responses.

Particle and fibre toxicology·2026
Same author

Sterile Inflammation in Mouse Lung Driven by Lipid Mediator Pathways Following MWCNT Exposure.

Chemical research in toxicology·2025
Same author

Pulmonary inflammatory and fibrogenic responses in rats following intratracheal instillation of dusts from natural and engineered stones.

Journal of toxicology and environmental health. Part A·2025
Same author

Establishing a novel combustion generator system to simulate and study emissions from diverse applications.

Inhalation toxicology·2025
Same author

RNA Sequencing Reveals Inflammatory and Metabolic Changes in the Lung and Brain After Carbon Black and Naphthalene Whole Body Inhalation Exposure in a Rodent Model of Military Burn Pit Exposures.

International journal of molecular sciences·2025
Same author

Maternal Electronic Cigarette Inhalation Exposure During Gestation: Impacts on Prolactin and Xanthine Oxidase.

Cardiovascular toxicology·2025
Same journal

Plastic signatures in childhood: first evidence of urinary micro- and nanoplastics in primary school children from Cyprus.

Particle and fibre toxicology·2026
Same journal

Pulmonary toxicity of micro- and nano polyethylene particles following intratracheal instillation in rats.

Particle and fibre toxicology·2026
Same journal

Degradation reshapes the toxic identity of polylactic acid microplastics through MSR1-dependent immune decoding in mouse kidney.

Particle and fibre toxicology·2026
Same journal

Bronchial mucosal nuclear transcription factor expression and inflammatory response in humans after exposure to wood smoke.

Particle and fibre toxicology·2026
Same journal

Surface-driven endocrine activity of nanoplastics: polymer- and size-dependent estrogen and androgen receptors modulation without steroidogenesis perturbation.

Particle and fibre toxicology·2026
See all related articles

Ultrafine particulate matter (PM) inhalation causes greater microvascular dysfunction than fine PM, even at equal lung loads. This suggests nanoparticles pose a higher risk to blood vessel function after breathing them in.

Area of Science:

  • Environmental Health
  • Toxicology
  • Cardiovascular Physiology

Background:

  • Pulmonary exposure to fine particulate matter (PM) impairs systemic arteriolar function.
  • Ultrafine PM, with its larger surface area, is hypothesized to be more toxic.
  • Previous studies indicate PM inhalation affects microvascular responses.

Purpose of the Study:

  • To compare the microvascular effects of ultrafine PM versus fine PM.
  • To determine if ultrafine particulate matter inhalation causes greater microvascular dysfunction.
  • To investigate the toxicity of ultrafine titanium dioxide (TiO2) aerosols.

Main Methods:

  • Rats were exposed to fine or ultrafine TiO2 aerosols at non-inflammatory concentrations.
  • In vivo microscopy assessed arteriolar dilation in the spinotrapezius muscle 24 hours post-exposure.

Related Experiment Videos

  • Endothelium-dependent dilation was evaluated using the Ca2+ ionophore A23187.

    • Main Results:

    • No significant lung inflammation or damage was observed histopathologically.
    • Fine TiO2 exposure blunted endothelium-dependent vasodilation proportionally to particle deposition.
    • Ultrafine TiO2 exposure resulted in arteriolar constriction or significantly impaired vasodilation compared to controls and fine PM exposure.

    Conclusions:

    • Ultrafine TiO2 inhalation induces greater remote microvascular dysfunction than fine TiO2 at equivalent pulmonary loads.
    • These findings highlight the increased toxicity of ultrafine particles on vascular function.
    • The study suggests a differential impact of particle size on systemic microvascular health.