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Related Experiment Video

Updated: Jul 7, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

[Atherogenesis: a dysimmune disease].

Aditi Varthaman¹, Jamila Khallou-Laschet, Olivier Thaunat

¹Inserm, UMR S 872, Les Cordeliers, Paris, F-75006 France.

Medecine Sciences : M/S

|February 15, 2008

Summary

Atherosclerosis involves the immune system, with T cells promoting disease and B cells protecting against it. Balancing these adaptive immune responses is crucial for effective atherosclerosis treatment.

Area of Science:

Immunology
Cardiovascular Disease Research

Context:

Atherosclerosis development is intricately linked to the immuno-inflammatory response.
Adaptive immune system players, including T cells and B cells, are implicated in atherogenesis.
Modified self-antigens and autoreactive immune cells are present in atherosclerotic lesions.

Purpose:

To explore the role of the adaptive immune system in atherosclerosis.
To characterize pro-atherogenic T cells and athero-protective B cells.
To evaluate the autoimmune criteria in the context of atherosclerosis.

Summary:

The study highlights the central role of the immuno-inflammatory response in atherosclerosis.
Evidence suggests atherosclerosis may meet autoimmune disease criteria, with modified self-molecules acting as antigens.

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Published on: December 15, 2011

Granulocyte-dependent Autoantibody-induced Skin Blistering

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Published on: October 12, 2012

While T cells contribute to atherosclerosis, B cells demonstrate a protective effect.

Impact:

Understanding the balance between T and B cell responses is key for developing novel therapeutic strategies for atherosclerosis.
This research provides insights into the complex autoimmune nature of atherosclerosis.
Identifies potential therapeutic targets within the adaptive immune system for cardiovascular disease.