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Adapting proteostasis for disease intervention.

William E Balch1, Richard I Morimoto, Andrew Dillin

  • 1Department of Cell Biology and Institute for Childhood and Neglected Diseases, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Science (New York, N.Y.)
|February 16, 2008
PubMed
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Maintaining protein homeostasis (proteostasis) is vital for cell health, development, and preventing diseases. The proteostasis network regulates protein integrity, and its dysfunction causes numerous disorders.

Area of Science:

  • Cellular Biology
  • Biochemistry
  • Molecular Biology

Background:

  • Eukaryotic cells constantly face threats to protein integrity.
  • Protein homeostasis (proteostasis) is crucial for healthy development, aging, and disease prevention.
  • Dysfunctional proteostasis is linked to various diseases, including metabolic, oncological, neurodegenerative, and cardiovascular disorders.

Purpose of the Study:

  • To describe the proteostasis network and its role in maintaining cellular and organismal health.
  • To highlight the therapeutic potential of targeting the proteostasis network for disease treatment.

Main Methods:

  • This study provides a descriptive overview of the proteostasis network.
  • It discusses the mechanisms involved in maintaining protein integrity within eukaryotic cells.

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Main Results:

  • The proteostasis network comprises interacting activities essential for proteome health.
  • Deficiencies in proteostasis are implicated in a wide range of severe diseases.
  • Targeting proteostasis regulators offers potential therapeutic strategies.

Conclusions:

  • The proteostasis network is fundamental to cellular and organismal well-being.
  • Understanding and manipulating proteostasis holds promise for treating challenging diseases.