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Androstanediolglucuronide: a parameter for peripheral androgen activity before and during therapy with cyproterone
G A Ponjee1, H A de Rooy, H L Vader
1St. Joseph Hospital, Clinical Laboratories, Veldhoven, The Netherlands.
Acta Endocrinologica
|April 1, 1991
Summary
Serum 5 alpha-androstane-3 alpha,17 beta-diolglucuronide (3 alpha-AdiolG) effectively monitors peripheral androgen action in hirsutism patients. Treatment with cyproterone acetate significantly reduces both 3 alpha-AdiolG levels and excessive hair growth.
Area of Science:
- Endocrinology
- Andrology
- Dermatology
Background:
- Hirsutism, characterized by excessive hair growth, is often linked to androgen excess.
- Assessing peripheral androgen action is crucial for understanding and managing hirsutism.
Purpose of the Study:
- To evaluate serum 5 alpha-androstane-3 alpha,17 beta-diolglucuronide (3 alpha-AdiolG) as a biomarker for peripheral androgen action in hirsutism.
- To assess the efficacy of cyproterone acetate in reducing 3 alpha-AdiolG levels and hirsutism.
Main Methods:
- Measured serum 3 alpha-AdiolG levels in patients with idiopathic hirsutism, polycystic ovary syndrome, and 21-hydroxylase deficiency.
- Scored hirsutism severity before and during treatment with cyproterone acetate.
- Analyzed the correlation between 3 alpha-AdiolG levels and the Quetelet Index.
Main Results:
- Significantly elevated serum 3 alpha-AdiolG levels were observed in hirsute patients compared to healthy controls.
- No significant correlation was found between 3 alpha-AdiolG levels and the Quetelet Index.
- Treatment with cyproterone acetate significantly decreased both 3 alpha-AdiolG levels and hirsutism scores.
Conclusions:
- Serum 3 alpha-AdiolG is a reliable parameter for assessing peripheral androgen action in hirsutism.
- Cyproterone acetate is effective in managing hirsutism by reducing androgen activity.