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Updated: Jul 7, 2026

Isolation, Characterization and MicroRNA-based Genetic Modification of Human Dental Follicle Stem Cells
Published on: November 16, 2018
Stem cells: potential therapeutics for periodontal regeneration
Karina Gonzales Silvério1, Bruno Braga Benatti, Márcio Zaffalon Casati
1Department of Prosthodontics and Periodontics, Division of Periodontics, School of Dentistry at Piracicaba, UNICAMP, Av. Limeira 901, CEP: 13414-903, Piracicaba, São Paulo, Brazil. kgsilverio@yahoo.com.br
Dental-derived stem cells show promise for tissue regeneration. This review explores their characterization and potential to improve periodontal regeneration beyond current methods.
Area of Science:
- Stem Cell Biology
- Periodontology
- Regenerative Medicine
Background:
- Conventional periodontal regeneration techniques have limitations.
- Complete and reliable periodontal tissue regeneration remains a challenge.
- Dental-derived stem cells offer potential therapeutic avenues.
Purpose of the Study:
- To review the characterization of dental-derived stem cells.
- To explore the potential of these cells in periodontal tissue regeneration.
- To highlight their advantages over existing periodontal treatments.
Main Methods:
- In vitro characterization of dental-derived stem cells.
- In vivo assessment of dental-derived stem cell efficacy.
- Literature review on periodontal regeneration strategies.
Main Results:
- Dental-derived stem cells exhibit multipotent differentiation capabilities.
- Evidence suggests these cells can promote periodontal tissue repair.
- Their regenerative potential surpasses current conventional methods.
Conclusions:
- Dental-derived stem cells are a promising source for periodontal regeneration.
- Further research can optimize their clinical application.
- These cells may revolutionize periodontal therapy.
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