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Published on: August 9, 2024
Actinic cheilitis: clinical and histological features
Ana Sueli Rodrigues Cavalcante1, Ana Lia Anbinder, Yasmin Rodarte Carvalho
1Department of Bioscience and Oral Diagnosis, School of Dentistry of São José dos Campos, São Paulo State University, São José dos Campos, São Paulo, Brazil. anasueli@fosjc.unesp.br
Summary
Actinic cheilitis (AC) presents with dryness and scaly lesions, and histological analysis reveals dysplasia. The degree of dysplasia in AC is not associated with patient gender, age, race, or smoking habits.
Area of Science:
- Dermatology
- Oral Pathology
- Oncology
Background:
- Actinic cheilitis (AC) is a potentially malignant disorder affecting the lip vermilion.
- Understanding its clinical and histological features is crucial for early diagnosis and management.
Purpose of the Study:
- To analyze the clinical and histological characteristics of actinic cheilitis (AC).
- To investigate the relationship between the degree of dysplasia and patient demographics and habits.
Main Methods:
- Clinical evaluation of 29 patients diagnosed with AC.
- Incisional biopsies for histological analysis and dysplasia grading (mild, moderate, severe).
- Statistical analysis (chi-squared and Fisher's tests) to assess associations between dysplasia and gender, age, race, and smoking.
Main Results:
- Most patients were male (72.41%), over 40 (75.86%), white (93.10%), and non-smokers (72.41%).
- Common clinical findings included dryness, atrophy, and scaly lesions.
- Histologically, dysplasia was observed in 100% of cases, with severe dysplasia in 62.07%; elastosis, inflammatory infiltrate, and vasodilatation were also frequent.
- No significant association was found between the degree of dysplasia and gender, age, race, or smoking habits.
Conclusions:
- Dryness, atrophy, and scaly lesions are key clinical indicators of AC.
- Histological findings of dysplasia, inflammation, and elastosis are characteristic of AC.
- Demographic factors and smoking habits do not influence the severity of dysplasia in actinic cheilitis.
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