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Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor

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Tracking cancer cell proliferation on a CMOS capacitance sensor chip.

Somashekar Bangalore Prakash¹, Pamela Abshire

¹Department of Electrical and Computer Engineering/Institute for Systems Research, University of Maryland, College Park, MD 20742, United States. sombp@isr.umd.edu

Biosensors & Bioelectronics

|February 19, 2008

Summary

This study introduces a new capacitance sensor technique for real-time, non-invasive monitoring of living cell growth. The novel biosensor tracks cell proliferation in vitro without requiring labels.

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Area of Science:

Biophysics
Biotechnology
Electrical Engineering

Background:

Assessing cell proliferation is crucial for understanding biological processes and disease.
Current methods for monitoring cell growth can be invasive, time-consuming, or require labels.

Purpose of the Study:

To develop and validate a novel, non-invasive, label-free technique for real-time monitoring of anchorage-dependent cell proliferation using integrated capacitance sensors.
To demonstrate the feasibility of on-chip capacitance sensing for tracking cell adhesion and growth.

Main Methods:

Fabrication of a sensor chip using commercial 0.5microm, 2-poly 3-metal CMOS technology.
Utilizing integrated capacitance sensors to measure substrate coupling capacitances of cells cultured on-chip.
Employing charge sharing to map sensed capacitance values (fF range) to output voltage signals.
Investigating the biophysical phenomenon of counterionic polarization around cell bodies in response to electric fields.

Main Results:

Demonstrated sensor response to the adhesion and subsequent proliferation of MDA-MB-231 breast cancer cells on the chip surface.
Successfully mapped cell growth to measurable capacitance changes.
Validated the non-invasive and label-free nature of the capacitance sensing technique.

Conclusions:

On-chip capacitance sensing provides a miniaturized, easy-to-use, and real-time method for assessing cell proliferation in vitro.
This technique offers a promising alternative to existing cell monitoring methods, particularly for anchorage-dependent cells.
The developed sensor technology has potential applications in drug discovery, toxicology, and fundamental cell biology research.