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Heterotopic Hindlimb-to-Neck Transplantation in the Mouse: A Supermicrosurgical Model of Vascularized Composite Allotransplantation
Published on: April 10, 2026
Intravascular stenting (IVaS) for safe and precise supermicrosurgery.
Mitsunaga Narushima1, Isao Koshima, Makoto Mihara
1University of Tokyo Department of Plastic and Reconstructive Surgery, Tokyo, Japan. Sancho-ps@umin.ac.jp
Annals of Plastic Surgery
|February 19, 2008
Summary
Supermicrosurgery is challenging for tiny vessels. Intravascular stenting (IVaS) using nylon monofilaments enables precise, safe anastomosis of vessels as small as 0.15 mm, achieving 100% patency.
Area of Science:
- Vascular surgery
- Microsurgery techniques
- Biomaterials in surgery
Background:
- Supermicrosurgery involving vessels <0.5 mm diameter presents challenges.
- Difficulties include forceps manipulation and inadvertent back wall catching during anastomosis.
- Existing methods struggle with precise vessel wall control in ultra-small caliber vessels.
Purpose of the Study:
- To evaluate the efficacy of intravascular stenting (IVaS) using nylon monofilaments for supermicrosurgery.
- To assess the safety and patency rates of IVaS in small vessel anastomosis.
- To demonstrate the feasibility of IVaS for vessels with diameters down to 0.15 mm.
Main Methods:
- Implantation of superficial inferior epigastric arterial (SIEA) flaps in 10 rats.
- Performance of supermicroanastomosis (0.15 mm diameter) using SIEA flaps in mice.
- Application of intravascular stenting (IVaS) with selectable nylon monofilaments.
Main Results:
- The IVaS method prevented inadvertent back wall catching in all cases.
- Immediate vascular patency rate achieved was 100%.
- Successful anastomosis of vessels with a minimum diameter of 0.15 mm was demonstrated.
Conclusions:
- Intravascular stenting (IVaS) with nylon monofilaments is a safe and effective technique for supermicrosurgery.
- IVaS facilitates precise and secure anastomosis of ultra-small vessels, overcoming previous limitations.
- This method offers versatility through selectable nylon sizes, enabling precise repair even in the smallest vessels.
