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Visualization of Bacterial Resistance using Fluorescent Antibiotic Probes
Published on: March 2, 2020
N-substituted 3-acetyltetramic acid derivatives as antibacterial agents
Raghunandan Yendapally1, Julian G Hurdle, Elizabeth I Carson
1Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.
Abstract:
In order to expand the structure-activity relationship of tetramic acid molecules with structural similarity to the antibiotic reutericyclin, 22 compounds were synthesized and tested against a panel of clinically relevant bacteria. Key structural changes on the tetramic acid core affected antibacterial activity. Various compounds in the N-alkyl 3-acetyltetramic acid series exhibited good activity against Gram-positive bacterial pathogens including Bacillus anthracis, Propionibacterium acnes, Enterococcus faecalis, and both Methicillin-sensitive and -resistant Staphylococcus aureus.
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