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Updated: Jul 7, 2026

Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile

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Published on: October 30, 2018

The wages of CIN.

Karen W Yuen¹, Arshad Desai

¹Ludwig Institute for Cancer Research, San Diego, La Jolla, CA 92093, USA. kayuen@ucsd.edu

The Journal of Cell Biology

|February 20, 2008

Summary

Chromosomal instability (CIN) in cancer cells stems from faulty attachments to the spindle that escape the cell cycle checkpoint. Induced aneuploidy is usually detrimental, suggesting tumors need more than just missegregated chromosomes to persist.

Area of Science:

Cell Biology
Cancer Research
Genetics

Background:

Aneuploidy and chromosomal instability (CIN) are common in solid tumors, yet their relationship is unclear.
CIN is investigated in cancer cells, focusing on its underlying mechanisms.

Discussion:

CIN originates from defective kinetochore-spindle attachments that bypass the spindle checkpoint, leading to anaphase errors.
The study examines the effects of experimentally induced chromosome missegregation in normal cells.

Key Insights:

Defective kinetochore-spindle attachments are a primary driver of CIN in cancer.
Artificially induced aneuploidy is typically selected against in otherwise normal cells.

Outlook:

The persistence of aneuploid cells in tumors likely requires additional undefined events beyond chromosome missegregation.

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Further research is needed to elucidate the factors enabling aneuploid cell survival in cancer.