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Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

Phase II Reactions: Methylation Reactions

Phase II Reactions: Methylation Reactions

Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...

Carboxylic Acids to Methylesters: Alkylation using Diazomethane

Carboxylic Acids to Methylesters: Alkylation using Diazomethane

Carboxylic acids react with diazomethane in an ether solvent via alkylation at the carboxylate oxygen atom to give methyl esters of the corresponding acid with excellent yields.

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Related Experiment Video

Updated: Jul 7, 2026

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Published on: August 5, 2022

[DNA methylation and prostate cancer].

Shui-Gen Zhou¹, Ying-Hao Sun, Jian-Ping Gao

¹Department of Urology, Nanjing General Hospital of Nanjing Military Command, PLA, Nanjing, Jiangsu 210002, China.

Zhonghua Nan Ke Xue = National Journal of Andrology

|February 21, 2008

Summary

DNA methylation, a key process in cancer, is altered in prostate cancer and its precursor lesions. Studying these DNA methylation changes offers new avenues for prostate cancer diagnosis and treatment.

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Methyl-binding DNA capture Sequencing for Patient Tissues

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Published on: October 31, 2016

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miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

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Last Updated: Jul 7, 2026

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Published on: August 5, 2022

Methyl-binding DNA capture Sequencing for Patient Tissues

Methyl-binding DNA capture Sequencing for Patient Tissues

Published on: October 31, 2016

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

Area of Science:

Epigenetics
Cancer Biology
Molecular Oncology

Context:

DNA methylation is a frequent epigenetic modification observed in various cancers, including prostate cancer.
Aberrant DNA methylation patterns are implicated in the initiation and progression of malignancies.
Genes involved in critical cellular functions, like DNA damage repair, are frequently hypermethylated in prostate cancer.

Purpose:

To investigate the role and patterns of DNA methylation in prostate cancer and its precursor lesions.
To explore the potential of DNA methylation as a biomarker for prostate cancer diagnosis and prognosis.

Summary:

DNA methylation is prevalent in prostate cancer, affecting genes crucial for cell processes like DNA repair.
Premalignant lesions, such as prostatic intraepithelial neoplasia, also exhibit DNA methylation changes, albeit to a lesser degree than in established cancer.
These findings highlight the significance of DNA methylation in prostate carcinogenesis.

Impact:

Understanding DNA methylation in prostate cancer can lead to novel strategies for early detection.
Aberrant methylation patterns may serve as prognostic indicators for patient outcomes.
Targeting DNA methylation pathways presents a potential therapeutic approach for prostate cancer treatment.