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Related Experiment Video

Updated: Jul 7, 2026

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice

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Published on: November 27, 2019

Leptin and its metabolic interactions: an update.

Anubhuti¹, Sarika Arora

¹Department of Biochemistry, GB Pant Hospital, New Delhi, India. anubhuti.vishesh@gmail.com

Diabetes, Obesity & Metabolism

|February 21, 2008

Summary

Leptin, a hormone from fat cells, controls body weight by regulating food intake and energy expenditure. Understanding leptin

Area of Science:

Endocrinology
Metabolism
Obesity Research

Background:

Obesity is characterized by abnormal white adipose tissue fat accumulation.
Leptin, a peptide hormone encoded by the obesity gene (ob), is secreted by adipocytes and plays a key role in regulating energy balance.

Purpose of the Study:

To review the biology, actions, and regulation of leptin.
To provide an update on recent findings regarding leptin's role in energy homeostasis and related pathologies.

Main Methods:

Review of existing scientific literature on leptin.
Analysis of genetic models and human studies related to leptin and obesity.

Main Results:

Leptin receptors (OB-R) are found in the central nervous system and peripheral organs, indicating autocrine and paracrine functions.

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Leptin exhibits a circadian secretion pattern in humans, peaking at midnight.

Leptin influences weight maintenance, energy balance sensing, and interacts with insulin and cholecystokinin.

Conclusions:

Leptin is a critical regulator of food intake, energy expenditure, and adiposity.
Leptin's roles extend beyond weight maintenance, potentially influencing obesity-associated conditions like atherosclerosis, oxidative stress, and cancer.