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Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Published on: April 27, 2016

Pressure ulcers and endothelial dysfunction: is there a link?

Bryan D Struck¹, Jonelle E Wright

¹Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, USA. bryan-struck@ouhsc.edu

Journal of Nutrition for the Elderly

|February 21, 2008

Summary

Pressure ulcers remain a significant clinical problem despite existing prevention strategies. This review explores the potential link between endothelial dysfunction and pressure ulcer development, suggesting new research directions.

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Area of Science:

Medical Research
Clinical Practice
Translational Science

Background:

Pressure ulcers, a persistent clinical challenge since the 16th century, cause patient suffering and increase healthcare costs.
Current prevention and treatment strategies, addressing factors like pressure, shear, friction, moisture, and malnutrition, are insufficient.
Endothelial dysfunction, a known cardiovascular risk factor, is emerging as a potential, yet understudied, contributor to pressure ulcer development.

Purpose of the Study:

To review the existing literature on pressure ulcers and endothelial dysfunction.
To build an argument for investigating the role of endothelial function in pressure ulcer etiology.
To propose endothelial function research as a valuable translational investigation.

Main Methods:

Literature review and synthesis.
Analysis of established pressure ulcer risk factors.
Exploration of the connection between endothelial dysfunction and pressure ulcer pathogenesis.

Main Results:

Established risk factors for pressure ulcers are well-documented but do not fully explain incidence.
A significant knowledge gap exists regarding the specific mechanisms linking endothelial dysfunction to pressure ulcers.
Endothelial dysfunction presents a plausible, under-explored pathway for pressure ulcer development.

Conclusions:

Investigating endothelial function offers a promising avenue for advancing the understanding of pressure ulcer development.
Translational research into endothelial dysfunction could significantly improve current prevention and treatment practices.
Further research is warranted to elucidate the precise role of endothelial dysfunction in pressure ulcer formation and management.