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Ursodeoxycholic acid treatment improves hepatocyte ultrastructure in rat liver fibrosis
Nuket Mas1, Ilker Tasci, Bilgin Comert
1Department of Anatomy, Kocatepe University, School of Medicine, Afyon, Turkey.
Aim:
To examine the ultrastructural changes after ursodeoxycholic acid (UDCA) treatment in hepatocytes from experimentally induced fibrotic livers.
Methods:
Liver fibrosis was induced in male Sprague-Dawley rats with CCl4 for 12 wk, and the rats were divided into two groups. Group I was treated with saline and group II with UDCA (25 mg/kg per day) for 4 wk. All the rats were killed at wk 16. Mitochondria, nuclei, rough endoplasmic reticulum (RER) and smooth endoplasmic reticulum (SER) of hepatocytes were evaluated according to a scoring system.
Results:
Mitochondria, nuclei, RER and SER injury scores in group II were significantly lower than those in group I (P < 0.001).
Conclusion:
UDCA alleviates hepatocyte organelle injury in CCl4-induced liver fibrosis.
