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Do rheological variables play a role in diabetic peripheral neuropathy?
S M MacRury1, J C Lockhart, M Small
1Diabetic Unit, Glasgow Royal Infirmary, UK.
Summary
Diabetic patients show altered blood viscosity compared to controls. However, blood rheology differences were similar in diabetic patients with and without peripheral neuropathy, suggesting it may not play a key role in neuropathy development.
Area of Science:
- Rheology
- Diabetology
- Neurology
Background:
- Diabetic peripheral neuropathy is a common complication.
- Microvascular factors are implicated in its etiology.
- Blood rheology, including whole blood viscosity, is a potential contributing factor.
Purpose of the Study:
- To investigate if whole blood viscosity and its determinants differ between diabetic patients with and without peripheral neuropathy.
- To assess the role of blood rheology in the microvascular etiology of diabetic peripheral neuropathy.
Main Methods:
- Whole blood viscosity, plasma viscosity, and red cell filtration ratio were measured.
- Measurements were taken at high and low shear rates.
- Diabetic patients with and without neuropathy were compared to non-diabetic controls.
Main Results:
- Diabetic patients exhibited significantly higher whole blood viscosity and plasma viscosity, and lower red cell filtration ratio compared to non-diabetic controls (p < 0.001).
- No significant differences in these rheological parameters were found between diabetic patients with and without peripheral neuropathy.
- Blood rheology alterations were comparable in diabetic patients irrespective of neuropathy status.
Conclusions:
- While diabetes significantly alters blood rheology, these changes are similar in patients with and without peripheral neuropathy.
- Blood rheology may not be a primary determinant in the development of microvascular complications leading to diabetic peripheral neuropathy.