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Using GenBank.

David Wheeler1

  • 1National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD, USA.

Methods in Molecular Biology (Clifton, N.J.)
|February 22, 2008
PubMed
Summary
This summary is machine-generated.

GenBank is a vital DNA sequence database covering over 205,000 organisms. It offers daily updates and global access through the National Center for Biotechnology Information (NCBI) for research and analysis.

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Area of Science:

  • Bioinformatics
  • Genomics
  • Molecular Biology

Background:

  • GenBank is a critical public repository for DNA sequences.
  • It encompasses data from over 205,000 named organisms, including extensive coverage of embryophyta.
  • Data is sourced from individual labs and large-scale sequencing initiatives.

Purpose of the Study:

  • To describe the GenBank database and its accessibility.
  • To highlight its integration with other NCBI resources.
  • To outline methods for accessing and analyzing sequence data.

Main Methods:

  • GenBank data is maintained through daily exchanges with EMBL and DDBJ.
  • Access is provided via the NCBI Entrez retrieval system.
  • Sequence similarity searches are performed using BLAST.

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Main Results:

  • GenBank provides comprehensive DNA sequence data for a vast number of organisms.
  • It integrates with diverse biological information, including protein sequences, genomes, and literature.
  • Both FTP and web-based tools facilitate data access and analysis.

Conclusions:

  • GenBank is an essential, globally accessible resource for molecular biology research.
  • Its integration with NCBI tools enhances data retrieval and analysis capabilities.
  • Regular updates ensure the database remains current and comprehensive.