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Updated: Jul 7, 2026
08:01
Stimulation of Notch Signaling in Mouse Osteoclast Precursors
Published on: February 28, 2017
Notch signaling in leukemias and lymphomas
Franziska Jundt1, Rolf Schwarzer, Bernd Dörken
1Department of Hematology and Oncology, Charité, Campus Virchow-Klinikum, University Medicine Berlin, 13353 Berlin, Germany. fjundt@mdc-berlin.de
Current Molecular Medicine
|February 22, 2008
Summary
Aberrant Notch signaling drives cancer, particularly T-cell acute lymphoblastic leukemia (T-ALL) and lymphomas. Targeting Notch pathways offers a promising therapeutic strategy for these hematopoietic neoplasms.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Aberrant Notch activation, identified in 1991 with Notch1 in T-cell acute lymphoblastic leukemias (T-ALL), is implicated in various cancers.
- Oncogenic Notch signaling influences critical cellular processes including differentiation, proliferation, survival, and angiogenesis in both solid and hematopoietic neoplasms.
Purpose of the Study:
- To review recent findings on Notch signaling in leukemias and lymphomas.
- To explore the role of Notch signaling in maintaining malignant stem cells in hematopoietic neoplasms.
Main Methods:
- Literature review of recent studies on Notch signaling in hematopoietic malignancies.
- Analysis of Notch pathway involvement in T-ALL, T-cell lymphomas, and B-cell lymphomas.
Main Results:
- Notch signaling plays a crucial role in the induction and progression of T-ALL.
- Recent findings highlight Notch's involvement in the pathogenesis of human T- and B-cell lymphomas.
- Notch signaling is a potential therapeutic target for hematopoietic neoplasms.
Conclusions:
- Notch signaling is a key driver in leukemias and lymphomas.
- Targeting Notch pathways presents a promising therapeutic avenue for treating these cancers.
- Further research into Notch's role in malignant stem cell maintenance is warranted.
Related Concept Videos
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
01:20The JAK-STAT Signaling Pathway
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
01:15Differentiation of Common Myeloid Progenitor Cells
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
02:54Canonical Wnt Signaling Pathway
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...