Experimental models of abdominal aortic aneurysms: an overview

Area of Science:

• Vascular Surgery
• Medical Research
• Biomedical Engineering

Background:

• Abdominal aortic aneurysms (AAAs) pose significant health risks, necessitating research into their development and treatment.
• Understanding AAA pathophysiology has been advanced by various experimental models over the past 50 years.

Purpose of the Study:

• To review and discuss the clinical significance of diverse experimental models for abdominal aortic aneurysms (AAAs).
• To highlight the role of these models in advancing therapeutic strategies for AAA management.

Main Methods:

• Review of established experimental models for abdominal aortic aneurysms (AAAs).
• Discussion of the application of these models in developing conservative, surgical, and endovascular treatments.
• Exploration of the use of animal models in endovascular graft and percutaneous technique development.

Main Results:

• Experimental models have been instrumental in elucidating AAA pathophysiological mechanisms.
• These models have facilitated the development of numerous pharmacological and surgical interventions for AAAs.
• Recent models have contributed to novel endovascular techniques and surgeon training.

Conclusions:

• Experimental AAA models are essential for understanding disease progression and evaluating new treatments.
• Continued development and utilization of these models are vital for improving AAA management and patient outcomes.
• Animal models are critical for the clinical translation of innovative endovascular procedures.