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An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells
Published on: July 20, 2014
REG Ialpha protein expression in Barrett's esophagus
Daisuke Chinuki1, Yuji Amano, Shunji Ishihara
1Department of Gastroenterology and Hepatology, Shimane University, School of Medicine, Izumo, Japan.
Journal of Gastroenterology and Hepatology
|February 22, 2008
Summary
Regenerating gene (REG) protein is expressed in Barrett's esophagus, particularly in cases with squamous re-epithelialization. This finding may link REG to Barrett's esophagus pathophysiology and progression.
Area of Science:
- Gastroenterology
- Oncology
- Molecular Biology
Background:
- Accelerated cellular proliferation in Barrett's esophagus is linked to malignant transformation.
- Growth factors are potentially involved in Barrett's esophagus pathophysiology.
- Regenerating gene (REG) connects mucosal inflammation and gastrointestinal carcinogenesis.
Purpose of the Study:
- To determine REG expression in Barrett's esophagus.
- To investigate the correlation between REG protein expression and clinicopathological factors in Barrett's esophagus.
Main Methods:
- 266 patients with Barrett's esophagus were analyzed.
- Immunohistochemistry was used to assess REG Ialpha protein expression.
- Multivariate logistic regression analyzed correlations with clinicopathological factors.
Main Results:
- REG Ialpha protein expression was found in 18.0% of patients.
- Expression correlated with squamous re-epithelialization, hiatal hernia, and age.
Conclusions:
- This study first demonstrates REG expression in Barrett's esophagus.
- REG Ialpha expression is more common in patients with squamous re-epithelialization.
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