Related Experiment Video
Updated: Jul 7, 2026
Immunohistochemical Staining of B7-H1 (PD-L1) on Paraffin-embedded Slides of Pancreatic Adenocarcinoma Tissue
Published on: January 3, 2013
[Immunoexpression of p53 and cyclin D1 in adenomas of the gallbladder]
F Arévalo1, C Arias Stella, E Monge
1Instituto de Anatomía Patológica y Biológica Molecular Arias Stella, Universidad Nacional Mayor, Lima, Perú. fer13013@hotmail.com
Introduction:
Gallbladder adenomas are infrequent neoplasms whose relation to adenocarcinoma is not well understood. It has been suggested that adenomas and adenocarcinomas follow different molecular pathways.
Material And Methods:
This is a comparative, cross-sectional study in which we compared p53 and D1 cyclin expression in adenomas and adenocarcinomas of the gallbladder.
Results:
We included 12 cases in each group. Expression of p53 occurred in 83.3% of adenocarcinomas and in 16.6% of adenomas (p = 0.003). D1 cyclin was expressed in a similar number of adenomas and adenocarcinomas.
Conclusion:
Our results support the hypothesis that p53 is an important step in the pathogenesis of adenocarcinomas but not of adenomas of the gallbladder. D1 cyclin is apparently a common pathway involved in the genesis of both tumors.
