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Intact DNA in ancient permafrost.

Kim Lewis1, Slava Epstein, Veronica G Godoy

  • 1Department of Biology, Northeastern University, Boston, MA 02115, USA. k.lewis@neu.edu

Trends in Microbiology
|February 23, 2008
PubMed
Summary

Ancient bacteria, contrary to popular belief, may survive for extended periods. Non-spore-forming bacteria in ancient samples show intact DNA and evidence of DNA repair, challenging traditional views on microbial longevity.

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Area of Science:

  • Microbiology
  • Molecular Biology
  • Geology

Background:

  • Traditionally, microbial survival in ancient samples is attributed to resilient spores.
  • Non-spore-forming bacteria were presumed to be non-viable in ancient environments.

Purpose of the Study:

  • To investigate the viability of non-spore-forming bacteria in ancient samples.
  • To challenge the prevailing notion that only spores can survive over geological timescales.

Main Methods:

  • Analysis of DNA integrity in ancient bacterial samples.
  • Assessment of DNA repair mechanisms in ancient non-spore-forming bacteria.

Main Results:

  • Non-spore-forming bacteria in ancient samples exhibit intact DNA.
  • Evidence suggests these bacteria possess DNA repair capabilities.
  • These ancient bacteria appear to fare better than spores.

Conclusions:

  • Ancient non-spore-forming bacteria may remain viable for extended periods.
  • The findings challenge the definition of "alive" in ancient microbial contexts.
  • Further research is needed to classify these ancient bacterial states (e.g., persisters, slow-growing cells).