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Updated: Jul 7, 2026

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

[Profile of endothelial dysfunction in arterial hypertension. Vascular ultrasound assessment]

Viviana Aursulesei1, Georgeta Datcu, M D Datcu

  • 1Universitatea de Medicină şi Farmacie Gr. T. Popa Iaşi, Facultatea de Medicină, Clinica I Medicală Cardiologică.

Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi
|February 26, 2008
PubMed

Insights

This study shows endothelial dysfunction is common in hypertension and varies greatly between individuals. Treatment can improve this dysfunction, highlighting the need for comprehensive vascular ultrasound assessments.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology

Background:

  • Arterial hypertension is frequently associated with endothelial dysfunction.
  • Brachial ultrasound assessment of flow-mediated dilation is a standard noninvasive method for evaluating endothelial function.
  • Endothelial dysfunction has prognostic implications in hypertensive patients.

Purpose of the Study:

  • To assess endothelial dysfunction in hypertensive patients using vascular ultrasound.
  • To evaluate the variability and treatability of endothelial dysfunction.
  • To explore novel parameters like velocity ratio and normalized diameter ratio.

Main Methods:

  • Prospective, long-term follow-up of 92 carefully selected hypertensive patients.
  • Utilized technical guidelines for vascular ultrasound assessment.
  • Employed a comprehensive approach evaluating multiple parameters of endothelial function.

Main Results:

  • Confirmed the presence of endothelial dysfunction in hypertensive individuals.
  • Demonstrated significant interindividual variability in endothelial dysfunction.
  • Showed that endothelial dysfunction can be improved with appropriate treatment.
  • Introduced and tested the velocity ratio and normalized diameter ratio as potential new parameters.

Conclusions:

  • Comprehensive assessment of endothelial dysfunction using vascular ultrasound is crucial in hypertension management.
  • Endothelial dysfunction in hypertension is variable but responsive to treatment.
  • Novel parameters like velocity ratio may offer additional insights into vascular health.
Abstract

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