Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Microbial Biosensors

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

LRP1 Activation Promotes Metabolic Reprogramming and Mrc1 Expression to Attenuate LPS-Induced Cognitive Deficits: An Integrated Omics Analysis.

CNS neuroscience & therapeutics·2026

Same author

A Portable Colorimetric Device for Rapid Bacterial Detection with Cleavable Functional Nucleic Acid Probes for A Common Bacterial Endoribonuclease.

Angewandte Chemie (International ed. in English)·2026

Same author

Engineering High-Performance Aptamers via Optimized SELEX and Structure-Guided Dimer Assembly for Clinical Malaria Diagnostics.

Analytical chemistry·2026

Same author

Metabolic syndrome and the risk of perioperative ischemic stroke in non-cardiac surgery: a case-control retrospective study.

Frontiers in endocrinology·2026

Same author

A general strategy to enhance aptamer affinity by suppressing dissociation through symmetric assembly.

Nucleic acids research·2026

Same author

Translating a miRNA Signal into Physical Immunomodulation via Programmed DNA Network Assembly on Mitochondria.

Journal of the American Chemical Society·2026

Same journal

Toward Sustainable Optics: Fully Biomass-Based Vitrimer Film for Near-Infrared Transparency.

Biomacromolecules·2026

Same journal

Poly(furfuryl alcohol) as a Surface Modifier for Cellulose Nanocrystals Reinforced HDPE Nanocomposites.

Biomacromolecules·2026

Same journal

Cutinase Adsorption to Polyester Surfaces Modulates Dissolved Oligomer Speciation during Enzymatic Depolymerization.

Biomacromolecules·2026

Same journal

Controlled Synthesis of Sulfated Glycopolypeptides as Heparin Mimics via <i>N</i>-Carboxyanhydride ROP for Anticoagulant Property.

Biomacromolecules·2026

Same journal

Ligno-Suberized Fruit Periderm as a Mechanically Reinforced Biomacromolecular Composite.

Biomacromolecules·2026

Same journal

Effect of Hydrophilic Brush Length and Hydrophobic Chain on Biodistribution of Polymethacrylate-Based Statistical Copolymers.

Biomacromolecules·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 7, 2026

Microembossing: A Convenient Process for Fabricating Microchannels on Nanocellulose Paper-Based Microfluidics

Microembossing: A Convenient Process for Fabricating Microchannels on Nanocellulose Paper-Based Microfluidics

Published on: October 6, 2023

Microgel-based inks for paper-supported biosensing applications.

Shunxing Su¹, Md Monsur Ali, Carlos D M Filipe

¹Department of Chemical Engineering and Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4L7, Canada.

Biomacromolecules

|February 26, 2008

Summary

This summary is machine-generated.

Researchers developed paper-based biosensors using microgels functionalized with antibodies or DNA aptamers. These novel biosensing inks maintain molecular recognition capabilities for inexpensive biodetection applications.

More Related Videos

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Published on: February 16, 2018

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Published on: September 19, 2017

Related Experiment Videos

Last Updated: Jul 7, 2026

Microembossing: A Convenient Process for Fabricating Microchannels on Nanocellulose Paper-Based Microfluidics

Microembossing: A Convenient Process for Fabricating Microchannels on Nanocellulose Paper-Based Microfluidics

Published on: October 6, 2023

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Published on: February 16, 2018

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Published on: September 19, 2017

Area of Science:

Biotechnology
Materials Science
Analytical Chemistry

Background:

Paper-based biodetection offers a low-cost platform for diagnostics.
Developing stable and effective recognition elements for paper substrates is crucial.
Poly(N-isopropylacrylamide) microgels present a potential matrix for immobilizing biomolecules.

Purpose of the Study:

To develop functionalized microgels for paper-based biosensing.
To evaluate the retention of molecular recognition capabilities of antibodies and DNA aptamers immobilized on microgels.
To assess the accessibility of immobilized recognition elements during chromatographic elution.

Main Methods:

Preparation of paper strips printed with carboxylic poly(N-isopropylacrylamide) microgels.
Modification of microgels with either antibodies or DNA aptamers.
Testing the recognition capabilities and accessibility of immobilized probes during chromatographic elution.

Main Results:

Immobilized antibodies and DNA aptamers retained their specific recognition capabilities.
The microgel remained stationary during chromatographic elution.
Microgel-supported affinity probes were accessible to targets in the elution solution.

Conclusions:

Functionalized microgels are suitable for creating inexpensive paper-based biosensors.
Microgels provide a stable and accessible platform for immobilized biomolecular recognition elements.
This approach enables effective biodetection using paper substrates and chromatographic elution.