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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
Endophthalmitis caused by Bacillus species.
John J Miller1, Ingrid U Scott, Harry W Flynn
1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida, USA.
American Journal of Ophthalmology
|February 26, 2008
Summary
Endophthalmitis caused by Bacillus species frequently leads to poor vision. Vancomycin, aminoglycosides, and fluoroquinolones show effectiveness against Bacillus, while cephalosporins are less effective.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Microbiology
Background:
- Endophthalmitis is a serious intraocular infection.
- Bacillus species are a known cause of endophthalmitis, particularly post-traumatic.
Purpose of the Study:
- To analyze clinical characteristics, management strategies, and visual prognoses of Bacillus-associated endophthalmitis.
- To evaluate the in vitro antibiotic susceptibility of Bacillus isolates.
Main Methods:
- Retrospective case series of 22 patients with Bacillus endophthalmitis.
- Review of clinical data and treatment outcomes.
- In vitro antibiotic sensitivity testing on 21 Bacillus isolates.
Main Results:
- Most cases (67%) resulted from open globe injuries, often with intraocular foreign bodies.
- Presenting visual acuity was poor in many patients.
- Vancomycin, gentamicin, and fluoroquinolones demonstrated high in vitro effectiveness against Bacillus isolates, unlike cephalosporins.
Conclusions:
- Bacillus endophthalmitis is associated with poor visual outcomes.
- Vancomycin, aminoglycosides, and fluoroquinolones are recommended for treating Bacillus endophthalmitis.
- Cephalosporins appear to be less effective against Bacillus species.
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