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Related Concept Videos

Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

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Updated: May 11, 2026

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
09:19

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies

Published on: January 4, 2015

Prospects for stem cell-based therapy.

George Q Daley1, David T Scadden

  • 1Division of Hematology/Oncology, Children's Hospital Boston, Boston, MA 02115, USA. george.daley@childrens.harvard.edu

Cell
|February 26, 2008
PubMed
Summary
This summary is machine-generated.

Regenerative medicine aims to repair tissues using stem cells. Therapies for genetic diseases involve engineering stem cells, but clinical application faces technical challenges.

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Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats
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Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting

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Last Updated: May 11, 2026

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Area of Science:

  • Stem cell biology
  • Regenerative medicine
  • Genetic disease therapy

Background:

  • Somatic stem cells maintain and repair organs.
  • Regenerative medicine seeks to leverage these cells for therapeutic purposes.

Purpose of the Study:

  • To discuss the potential of stem cell-based therapies for tissue repair and genetic diseases.
  • To highlight the challenges in translating pluripotent human stem cell therapies to clinical practice.

Main Methods:

  • Review of current strategies in regenerative medicine.
  • Discussion of stem cell engineering for genetic defect correction.

Main Results:

  • Stem cell transplantation and pharmacological activation are key approaches.
  • Engineered stem cells offer potential for treating single-gene disorders.

Conclusions:

  • Significant technical hurdles remain for clinical application of pluripotent human stem cell therapies.
  • Further research is needed to overcome these challenges for effective regenerative medicine.