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Trapped-ion cell with improved DC potential harmonicity for FT-ICR MS.

Aleksey V Tolmachev1, Errol W Robinson, Si Wu

  • 1Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA.

Journal of the American Society for Mass Spectrometry
|February 26, 2008
PubMed
Summary

A new trapped-ion cell design for Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) improves performance. This optimized cell design enhances mass accuracy and signal intensity, crucial for advanced analytical applications.

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Area of Science:

  • Analytical Chemistry
  • Physical Chemistry

Background:

  • The trapped-ion cell is crucial for Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) performance.
  • Existing designs may limit optimal ion trapping and detection capabilities.

Purpose of the Study:

  • To develop and evaluate a novel trapped-ion cell design for FT-ICR MS.
  • To achieve a DC trapping potential closely approximating an ideal Penning trap.
  • To enhance mass measurement accuracy and signal intensity.

Main Methods:

  • Designed an open cylindrical cell with compensation segments for a 3D axial quadrupolar potential.
  • Performed electric potential calculations to minimize radial electric field variations.
  • Upgraded a 12 tesla FT-ICR MS instrument with the new cell and characterized its performance.
  • Conducted mass accuracy tests with multiple calibrants and varying ion populations.

Main Results:

  • The new cell design achieved a practically constant effective ion cyclotron frequency, independent of ion position.
  • Operating at larger post-excitation radii (0.7 of cell inner radius) improved mass accuracy and signal intensity.
  • Achieved under 0.05 ppm RMS precision for internal calibration with reduced ion populations.
  • Demonstrated twofold improvement in mass accuracy for increased ion populations compared to noncompensated cells.

Conclusions:

  • The developed trapped-ion cell design significantly enhances FT-ICR MS performance.
  • The cell design minimizes space charge effects, leading to superior mass accuracy.
  • This advancement is critical for high-performance mass spectrometry applications.