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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Long-term outcome in diabetic heart failure patients treated with cardiac resynchronization therapy

Cecilia Fantoni1, François Regoli, Ali Ghanem

  • 1Division of Cardiology, University Hospital, Magdeburg, Germany.

European Journal of Heart Failure
|February 26, 2008
PubMed

Insights

Diabetic patients with heart failure (HF) show similar positive outcomes to non-diabetic patients when treated with cardiac resynchronization therapy (CRT). This therapy improves function and survival rates for both groups, regardless of diabetes status.

Area of Science:

  • Cardiology
  • Diabetology
  • Medical Technology

Background:

  • Diabetes mellitus is a significant risk factor for heart failure (HF) complications.
  • Understanding treatment efficacy in diabetic HF patients is crucial.

Purpose of the Study:

  • To compare the effects of cardiac resynchronization therapy (CRT) on functional, structural, and long-term outcomes in diabetic versus non-diabetic HF patients.

Main Methods:

  • A comparative study of 141 diabetic and 214 non-diabetic HF patients receiving CRT.
  • Analysis of major adverse events (death, transplantation, LV assist device), hospitalizations, and CRT-D discharges.

Main Results:

  • CRT improved functional capacity, ventricular geometry, and neurohumoral balance in both groups over 34 months.
  • No significant differences in event-free survival, CRT-D interventions, or hospitalizations between diabetic and non-diabetic patients.
  • Multivariable analysis identified factors like NYHA class, LV ejection fraction, beta-blocker use, renal function, and lead presence, but not diabetes, as predictors of poor outcome.

Conclusions:

  • Diabetic HF patients experience comparable functional and survival benefits from CRT as non-diabetic patients.
  • CRT is an effective treatment option for improving outcomes in diabetic HF populations.
Abstract

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