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Mononuclear cell-bound CD23 is elevated in both atopic dermatitis and psoriasis.
1Department of Dermatology, Hôpital Cantonal Universitaire, Geneva, Switzerland.
Journal of Dermatological Science
|March 1, 1991
Summary
Elevated CD23 expression on B cells is linked to atopic dermatitis (AD) and psoriasis, but not specific to AD. This suggests CD23 is a general marker for B cell activation during inflammation.
Area of Science:
- Immunology
- Dermatology
Background:
- Patients with atopic dermatitis (AD) often exhibit elevated serum IgE levels.
- The role of CD23 (a low-affinity IgE receptor) and its soluble form (sCD23) in AD is not fully understood.
Purpose of the Study:
- To investigate the relationship between CD23 expression and atopic dermatitis.
- To compare CD23 levels in AD patients, psoriasis patients, and healthy individuals.
Main Methods:
- Examined CD23 expression on peripheral blood mononuclear cells (PBMC).
- Measured serum IgE and sCD23 levels.
- Compared findings in 33 AD patients, 9 psoriasis patients, and 10 healthy donors.
Main Results:
- CD23+ PBMC and adherent cells were significantly elevated in AD patients.
- Psoriasis patients also showed significantly elevated CD23 on PBMC and adherent cells.
- CD23 was detected only on B cells, not monocytes/macrophages.
- Cell-bound CD23 levels correlated with clinical AD severity.
- Serum sCD23 levels were not significantly increased in either patient group.
Conclusions:
- CD23 expression is elevated in both AD and psoriasis, indicating it is a nonspecific marker for B cell activation in inflammatory conditions.
- CD23 is not a specific biomarker for atopic dermatitis.