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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
MALDI-TOF Mass Spectrometry01:19

MALDI-TOF Mass Spectrometry

Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.Matrix-assisted laser desorption ionization (MALDI) is a commonly...
Rapid Identification of Pathogens01:25

Rapid Identification of Pathogens

MALDI-TOF MS has transformed clinical microbiology by offering a rapid and reliable method for pathogen identification. The traditional approach to microbial identification typically involves time-consuming culture techniques and biochemical tests, which can delay the initiation of appropriate antimicrobial therapy. MALDI-TOF MS avoids these delays by using characteristic ribosomal protein mass patterns of microbial cells, enabling accurate species-level identification within minutes.Principle...

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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

Proteomics, nanotechnology and molecular diagnostics.

Christopher J Johnson1, Nikolay Zhukovsky, Anthony E G Cass

  • 1Institute of Biomedical Engineering, Imperial College, London, UK.

Proteomics
|February 26, 2008
PubMed
Summary
This summary is machine-generated.

Nanomaterials offer solutions for proteomics and molecular diagnostics, establishing nanoproteomics as a new field. This advancement will enable the discovery of next-generation biomarkers for improved patient diagnosis.

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Last Updated: Jul 7, 2026

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Area of Science:

  • Biochemistry
  • Materials Science
  • Biotechnology

Background:

  • Human genome sequencing enables proteome exploration, identifying numerous proteins in biological samples.
  • Protein-based molecular diagnostics are emerging but face technical challenges.
  • Nanomaterials offer potential solutions to these challenges in proteomics.

Purpose of the Study:

  • To review the principles of nanomaterials and devices.
  • To outline their applications in proteomics, establishing the field of nanoproteomics.
  • To highlight their role in discovering next-generation biomarkers for molecular diagnostics.

Main Methods:

  • Review of physical and chemical principles of nanomaterials.
  • Discussion of nanomaterial applications in proteomics.
  • Exploration of nanoproteomics for biomarker discovery.

Main Results:

  • Nanomaterials provide a foundation for nanoproteomics.
  • Nanoproteomics is emerging as a significant new scientific field.
  • The integration of nanomaterials is crucial for advancing molecular diagnostics.

Conclusions:

  • Nanomaterials are key to overcoming technical hurdles in proteomics and molecular diagnostics.
  • Nanoproteomics will drive the discovery of novel biomarkers.
  • The field of molecular diagnostics is poised for significant advancement through nanoproteomics.