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Diversity of human rotavirus G9 among children in Turkey

Gulendam Bozdayi1, Bora Dogan, Buket Dalgic

  • 1Department of Medical Microbiology, Faculty of Medicine, Gazi University, Ankara, Turkey.

Journal of Medical Virology
|February 26, 2008
PubMed

Insights

Rotavirus infection is common in Turkish children, especially those under two years old. Diverse G9 rotaviruses are emerging, with year-round prevalence and varied G/P types, indicating a unique epidemiological profile.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Rotavirus is a leading cause of severe diarrheal disease in infants and young children globally.
  • Understanding the epidemiology and genetic diversity of rotavirus strains is crucial for vaccine development and public health strategies.

Purpose of the Study:

  • To investigate the epidemiology and molecular characteristics of rotavirus infections in children with diarrhea in Ankara, Turkey.
  • To identify dominant rotavirus serotypes, electropherotypes, and their genetic diversity.

Main Methods:

  • Prospective study conducted from September 2004 to December 2005.
  • Collection and analysis of 322 stool samples from children with diarrhea.
  • Rotavirus detection, serotyping (G/P types), electropherotyping, and phylogenetic analysis of VP7 and VP8* genes.

Main Results:

  • Rotavirus was detected in 39.7% of samples, predominantly in children aged 6-23 months.
  • The most common serotype was G1P[8], followed by G9P[8].
  • Phylogenetic analysis revealed that Turkish G9 strains clustered with lineage III and Ia, with one strain forming a new lineage (IV) with Sri Lankan strains.

Conclusions:

  • Rotavirus infection in Turkey shows a mixed epidemiological pattern, resembling developing countries in its year-round prevalence and G/P type diversity, but developed countries in later age of infection.
  • Emergence of diverse G9 rotaviruses in Turkey is suggested, highlighting the need for ongoing surveillance.

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