Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Integrin-dependent translational control: Implication in cancer progression.

Jun Chung1, Tae Hyong Kim

  • 1Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA. jchung@lsuhsc.edu

Microscopy Research and Technique
|February 27, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exosomal MicroRNAs as Drivers of Desmoplasia and Treatment Resistance in Breast Cancer: Mechanisms, Biomarker Potential, and Therapeutic Opportunities.

Biomolecules·2026
Same author

Quality-aware robotic frying of fragile sheet intermediates using a dual-slot gripper.

Current research in food science·2026
Same author

Clinical Characteristics and Risk Factors for Syphilis Among People Living With Human Immunodeficiency Virus: A Nationwide Population-Based Cohort Study in Korea.

Journal of Korean medical science·2026
Same author

Characteristics and geographical distribution of syphilis among people with human immunodeficiency virus and the National Population in Republic of Korea.

PloS one·2026
Same author

Hemodialysis vascular access infections: epidemiology and risk factors for treatment failure.

The Korean journal of internal medicine·2026
Same author

Exploring the Link between Mental Health and Treatment Adherence in People Living with HIV: A Structured Questionnaire-Based Study.

Infection & chemotherapy·2026
Same journal

Deep Learning Based Framework for Detection and Classification of Leukemia Using Microscopic Images.

Microscopy research and technique·2026
Same journal

Externally Controlled In Situ SEM: Multi-Rate Scanning With Signal Regulation and Spatiotemporal Fusion.

Microscopy research and technique·2026
Same journal

In Situ TEM Observation of Phase Transformation Nucleation at the Near-Surface of Synthetic Aragonite.

Microscopy research and technique·2026
Same journal

Morpho-Anatomical and HPTLC Investigations of Lysimachia nummularia L. (Primulaceae) Grown in Switzerland.

Microscopy research and technique·2026
Same journal

Macroscopic, Histological and Ultrastructural Features of the Tongue of the Anatolian Wild Boar (Sus scrofa libycus).

Microscopy research and technique·2026
Same journal

Ultrastructural Insights Into the Reproductive Anatomy and Eggs of Cotton Pink Bollworm, Pectinophora gossypiella Saunders (Lepidoptera: Gelechiidae).

Microscopy research and technique·2026
See all related articles

Integrins play a key role in cancer progression by controlling protein translation efficiency, particularly during initiation. This review explores how integrins regulate translation and impact cancer cell proliferation, survival, angiogenesis, and invasion.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Cell Biology

Background:

  • Translational control is crucial for cancer progression.
  • Cancer cells exhibit high translation efficiency, but the mechanisms are unclear.
  • Integrins are cell surface receptors involved in cell adhesion and signaling.

Purpose of the Study:

  • To summarize the role of integrins in translational control in cancer.
  • To discuss mechanisms by which integrins regulate translation initiation.
  • To examine the hypothesis that integrins promote cancer progression via translational control.

Main Methods:

  • Literature review of studies on integrins and translational control.
  • Analysis of mechanisms regulating translational machinery recruitment by integrins.

Related Experiment Videos

  • Examination of integrin-mediated effects on cancer hallmarks.

    • Main Results:

    • Integrins are implicated in regulating translation, especially at the initiation step.
    • Integrins influence the recruitment of the translational machinery.
    • Integrins may contribute to cancer proliferation, survival, angiogenesis, and invasion through translational regulation.

    Conclusions:

    • Integrins are critical regulators of translation in cancer cells.
    • Understanding integrin-mediated translational control offers insights into cancer progression.
    • Targeting integrin-translation interactions may present novel therapeutic strategies.