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[Study of long-term toxicity on applying Solanum lyratum on rat skin]
Xiang-yang Su1, Cai-hong Qu, Gan-yuan Zhang
1Dermatology Department, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Objective:
To observe the long-term toxicity of rats which we had applied Solanum lyratum Thunb gel on their skins daily for 90 days.
Methods:
We had applied high and low doses of Solanum lyratum Thunb gel one time each day on healthy and punctured rats skins respectively for 90 days. The rats' characters were observed, and their blood routines, blood biochemistry index, anatomic and pathologic changes of their major organs were also detected.
Results:
Rats' characters had no change, the results of all detections were normal. There was no significant difference between test groups and control group. Rats'major organs had no change in anatomy and pathology.
Conclusion:
No long-term toxic reaction can be found in the test of rats applied Solanum lyratum Thunb gel on their skins for a long term. It proves that it is safe using the normal dose of this gel on the skin in clinic.
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Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
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