Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Home Observation for Measurement of the Environment: Collecting Data Virtually.

Clinical pediatrics·2026
Same author

Prenatal Substance Exposure and Birth Weight: Findings From the HEALthy Brain and Child Development Study.

Pediatrics·2026
Same author

Wired from the womb: a narrative review of fetal and neonatal connectomics via fMRI and emerging neurotechnologies.

Pediatric research·2026
Same author

Feasibility of Non-Sedated Multispectral Neuroimaging in Newly Diagnosed Children with Leukemia.

medRxiv : the preprint server for health sciences·2026
Same author

Association of prenatal depression and anxiety with cortical development and behavioral outcomes in 8-year-old children.

Journal of affective disorders·2026
Same author

Maternal physical activity during pregnancy is associated with changes of brain cortical development and executive function in 8-year-old children.

Frontiers in human neuroscience·2026

Related Experiment Video

Updated: Jul 7, 2026

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
09:30

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Published on: December 18, 2016

MT effects and T1 quantification in single-slice spoiled gradient echo imaging.

Xiawei Ou1, Daniel Frank Gochberg

  • 1Department of Radiology, Vanderbilt University Institute of Imaging Science, Nashville, Tennessee 37232-2310, USA. xiawei.ou@vanderbilt.edu

Magnetic Resonance in Medicine
|February 28, 2008
PubMed
Summary
This summary is machine-generated.

Magnetization transfer (MT) effects slightly increase steady-state MR signals. This MT phenomenon can cause over 10% errors in T(1) values derived from conventional gradient echo imaging, impacting accuracy.

More Related Videos

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
09:59

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

Published on: September 16, 2017

Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery (SALLI) MRI in Rats
08:41

Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery (SALLI) MRI in Rats

Published on: July 19, 2013

Related Experiment Videos

Last Updated: Jul 7, 2026

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
09:30

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Published on: December 18, 2016

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
09:59

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

Published on: September 16, 2017

Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery (SALLI) MRI in Rats
08:41

Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery (SALLI) MRI in Rats

Published on: July 19, 2013

Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Biophysical Chemistry

Background:

  • Magnetization transfer (MT) is a crucial phenomenon in MRI, affecting signal quantification.
  • Understanding MT effects is vital for accurate tissue characterization and T(1) value determination.

Purpose of the Study:

  • To investigate the impact of MT on steady-state MR signals in spoiled gradient echo sequences.
  • To derive and validate a modified signal equation accounting for MT effects.
  • To assess the accuracy of conventional T(1) measurements in the presence of MT.

Main Methods:

  • Incorporated MT coupling terms for a two-pool system into the Bloch equations.
  • Derived a new steady-state signal equation including MT effects.
  • Compared the derived equation with the conventional one and tested with experimental samples (MnCl2, BSA).

Main Results:

  • MT effects were found to increase the steady-state MR signal by a few percent.
  • Conventional gradient echo methods can lead to over 10% T(1) errors, particularly in white matter with short repetition times (TR).
  • The modified signal equation accurately describes experimental data, enabling quantification of relaxation and MT parameters.

Conclusions:

  • MT significantly influences steady-state MR signals and conventional T(1) measurements.
  • Accurate MRI quantification requires incorporating MT effects into data analysis.
  • The developed theoretical framework and modified equation offer improved methods for characterizing tissue properties.