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Cytotoxic hydrolyzable tannins from Balanophora japonica
Zhi-Hong Jiang1, Xiao-Yun Wen, Takashi Tanaka
1School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, People's Republic of China. zhjiang@hkbu.edu.hk
Abstract:
Four hydrolyzable tannins named balanophotannins D-G ( 1- 4) were isolated from the aerial parts of the parasitic plant Balanophora japonica. Their structures were characterized on the basis of spectroscopic and chemical evidence. Balanophotannins D-G contain an oxidized hexahydroxydiphenoyl (HHDP) group. The absolute configurations of balanophotannins D ( 1) and F ( 3) were determined via the PGME method. Balanophotannin E ( 2) showed cytotoxicity to Hep G2 cancer cells with an IC 50 value of 4.22 microM.
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