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Atherosclerosis I: Introduction

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...

Atherosclerosis III: Management

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...

Atherosclerosis IV: Nursing Management

Atherosclerosis IV: Nursing Management

Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...

Acute Coronary Syndrome III: Diagnostic Studies

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...

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Related Experiment Video

Updated: May 26, 2026

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

Decoding atherosclerosis through lactylation: multi-omics integration with experimental validation.

Yirong Ma¹, Qiming Li¹, Muge Wang²

¹Department of Postgraduate, Jiangxi University of Chinese Medicine, Nanchang, China.

Frontiers in Cell and Developmental Biology

|May 25, 2026

Summary

This summary is machine-generated.

Lactylation-linked genes UAP1, NRP1, QPRT, and NDST1 show diagnostic potential for atherosclerosis (AS). NRP1 interaction with rivaroxaban is a promising therapeutic lead for AS.

Keywords:

atherosclerosis lactylation machine learning molecular dynamics proteomics

Related Experiment Videos

Last Updated: May 26, 2026

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

Area of Science:

Biochemistry
Molecular Biology
Cardiovascular Research

Background:

Atherosclerosis (AS) is a primary cause of cardiovascular disease.
Lactylation, a post-translational modification, is linked to vascular inflammation but its role in AS is unclear.

Purpose of the Study:

To investigate the role of lactylation in atherosclerosis.
To identify novel lactylation-related biomarkers for AS.
To explore potential therapeutic targets for AS.

Main Methods:

Data-independent proteomics and transcriptomics were used to analyze AS models.
Machine learning algorithms evaluated candidate biomarkers.
Immune infiltration and single-cell data characterized immune contexts.
In silico methods explored therapeutic interventions.

Main Results:

Proteomics and transcriptomics identified 25 candidate lactylation-related genes (LRGs).
A machine learning ensemble nominated UAP1, NRP1, QPRT, and NDST1 as hub genes with high diagnostic accuracy (AUC 0.979).
These hub genes are associated with immune cell infiltration and validated in vivo in Apoe-/- mice.
In silico analysis suggested a potential therapeutic interaction between NRP1 and rivaroxaban.

Conclusions:

UAP1, NRP1, QPRT, and NDST1 are potential lactylation-linked biomarkers for AS.
NRP1-rivaroxaban interaction presents a hypothesis for future therapeutic development in AS.