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Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma
12:03

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Published on: July 25, 2011

PET/CT for assessing mandibular invasion by intraoral squamous cell carcinomas

E Babin, C Desmonts, M Hamon

    Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
    |February 28, 2008
    PubMed

    Abstract:

    Evaluation of mandible invasion in cancer of the oral cavity and oropharynx is a major challenge. Today, CT scans are the most frequent imaging technique used, with sensitivity of 53 to 92% and specificity of 83 to 96%. Positron emission tomography is known as one of the most sensitive imaging techniques for head and neck cancer, but has poor anatomical resolution. Our study associates positron emission tomography with CT scans, fusioning both images to maximise data information. Positron emission tomography/CT fusion shows sensitivity of 100% with specificity of 85%. This result encourages the use of positron emission tomography/CT when assessing mandibular invasion.

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    Mouth Inspection
    The inspection begins with visually examining the mouth for symmetry, color, and size.

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