Related Experiment Video
Updated: Jul 7, 2026

Evaluation of Blood Lactate and Plasma Insulin During High-intensity Exercise by Antecubital Vein Catheterization
Published on: May 18, 2018
Gender impacts the post-exercise substrate and endocrine response in trained runners
Lisa M Vislocky1, P Courtney Gaine1, Matthew A Pikosky1
1Department of Nutritional Sciences, 3624 Horsebarn Hill Road Ext. Unit 4017, University of Connecticut, Storrs, Connecticut, USA.
This study reveals distinct sex differences in hormonal and metabolic recovery after endurance exercise. Females showed increased glucose, lactate, and insulin, while males exhibited altered growth hormone and IGF-I levels post-exercise.
Area of Science:
- Exercise Physiology
- Endocrinology
- Sports Science
Background:
- Limited research exists on sex-based differences in prolonged recovery from endurance exercise.
- Understanding these differences is crucial for optimizing training and recovery protocols.
Purpose of the Study:
- To compare endocrine and substrate profiles in trained male and female runners during a 3.5-hour recovery period post-endurance exercise.
- To identify sex-specific physiological responses to prolonged exercise recovery.
Main Methods:
- Trained male and female runners completed an endurance run at 70% VO2peak.
- Blood samples were collected at rest and during recovery to measure glucose, lactate, FFAs, insulin, cortisol, GH, and IGF-I.
- Participants maintained a standardized euenergetic diet for 8 days prior to testing.
Main Results:
- Females exhibited increased glucose, lactate, and insulin levels during recovery, unlike males.
- Males showed increased growth hormone (GH) and decreased free insulin-like growth factor I (IGF-I) levels.
- Free fatty acid (FFA) levels rose in both sexes, with no significant gender difference.
Conclusions:
- The findings highlight significant gender-specific differences in substrate and endocrine responses during prolonged recovery from endurance exercise.
- Further research is recommended to explore the impact of varying diets and nutritional supplements on these sex-specific post-exercise adaptations.
Related Concept Videos
Exercise and Muscle Performance
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Exercise and Cardiovascular Response
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Muscle Recovery and Fatigue
Exercise Stress Test
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes